Form: 10-K

Annual report pursuant to Section 13 and 15(d)

February 24, 2022

Exhibit 21

Subsidiaries of the Company:

Papa John’s USA, Inc., a Kentucky corporation

PJ Food Service, Inc., a Kentucky corporation

Trans Papa Logistics, Inc., a Kentucky corporation

Preferred Marketing Solutions, Inc., a Kentucky corporation

Papa John’s Franchising, LLC, a Kentucky limited liability corporation

Capital Delivery, Ltd., a Kentucky corporation

DEPZZA, Inc., a Delaware corporation

Colonel’s Limited, LLC, a Virginia limited liability company

PJ Holdings, LLC, a Delaware limited liability company

Star Papa, LP, a Delaware limited partnership company

Papa John’s Pizza, Ltd., a United Kingdom corporation

Papa John’s (GB), Ltd., a United Kingdom corporation

Papa John’s Corporate Stores Limited, a United Kingdom corporation

Papa John’s Mexico, Inc., a Delaware corporation

Papa John’s Capital, SRL de CV, a Mexican corporation

Equipo Papa John’s, SRL de CV, a Mexican corporation

Papa John’s EUM, SRL de CV, a Mexican corporation

PJ Mexico Franchising SRL de CV, a Mexican corporation

Papa John’s China, LLC, a Delaware limited liability company

PJ Chile, LLC, a Kentucky limited liability company

PJI Chile, SpA, a Chilean corporation

PJ North Georgia, LLC, a Kentucky limited liability company

PJFS Canada, LLC, a Kentucky limited liability company

PJ Asia, LLC, a Kentucky limited liability company

Papa John’s Korea, Limited, a Korean corporation

Papa John’s (Beijing) Commercial Management Company Limited – China corporation

O’Neal Boyz, LLC – a Georgia limited liability company

Papa John’s USA – Georgia, Inc., a Delaware corporation

PJ Russia, LLC – a Kentucky limited liability company

PJ Rus, LLC – a Russian limited liability company